Abstract: The activation of nuclear transcription factor κB has now been linked with a variety of inflammatory diseases, including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma, arthritis, Crohn's disease, multiple sclerosis, Alzheimer's disease, osteoporosis, psoriasis, septic shock, and AIDS.
Extensive research in the last few years has shown that the pathway that activates this transcription factor can be interrupted by phytochemicals derived from spices such as turmeric (curcumin), red pepper, cloves , ginger, cumin, anise, and fennel, basil and rosemary, garlic, and pomegranate (ellagic acid).
For the first time, therefore, research provides “reasoning for seasoning.”*
Suppression of the Nuclear Factor-κB Activation Pathway by Spice-Derived Phytochemicals: BHARAT B. AGGARWAL*, SHISHIR SHISHODIA.
Article first published online: 12 JAN 2006 - DOI: 10.1196/annals.1329.054